Gatwick-San Francisco is technically going to be operated soon with Norwegian starting flights to Oakland this year.
I also think that many more Italian, Spanish & French estinations could be operated from the UK, especially from Luton & Manchester. Also Gatwick could be receive much more long-haul services.
Does anyone have any suggestions for new easyJet routes from Gatwick? They haven't announced anything for S16, but could announce routes in W16.