Given the two Soyuz flights resulting in loss of crew were (according to Wikipedia) the 1st and 10th, and they've since flown 116 consecutive missions over 44 years (plus 2 in progress) with no fatalities, I think your assessment of 1:50 for the current hardware is a bit harsh.
The shuttle's 135 flights, with failures on flights 25 and 113, and arguably no real solution to the issue that led to the 2nd loss, paint a less encouraging picture.