At my outfit we set what we think the FL will be for the first hour or so at the preflight stage. Every time we change level after that we make sure the MCP, the FMC, and the Pressurization Controller all agree.
I see the logic in setting the higher altitude but have to say that I have never seen a problem with the way we do it. Is there an Engineering disadvantage to how we do it? Ie cycles of Pressurization weakening the fuselage?