I'm in my 30s now. Airlines are still buying A320s and 737 derivatives. I have little doubt that I will retire flying aircraft currently flying now. The 747 and 767 have been with BA 20-30 years. I look forward to retiring off maybe the 380 some time in the 2040s.
If you need one pilot on the aircraft, then quite frankly you need two. I think the vast majority of tasks will be automated, with various forms of computer control, but we are looking at the next generation of clean sheet designs, so 30-50 years away.