Absolutely - a 4-axis autopilot with a good rad alt hold is the minimum that should be mandated for night overwater work.
Add a TAS hold and a decent nav kit driving the aircraft in the right direction and, of course, NVG and you have a safe and managable setup.
If you have some transition modes as well you can get yourself to a comfortable position to hand-fly the remainder of the approach.
But, as already hinted at, you need to know how to use the autopilot modes and not get lost in them.