It's 444 miles from Nellis AFB to my brother's house in Reno. I've made the drive many times. I stop a lot, so I allow 12 hours. One can certainly do it in eight hours if butt and bladder endurance allow that.
It's decent fast pasted road and there are interesting towns (and some ghost towns) along the way. Tonapah is the main town close to the half way point, although sadly the Tonapah brothel closed years ago.
At night wild horses on the road are a real issue.
It's skirts the Nellis range complex, so you never know what kind of interesting airplane you might see.