I wouldn't say the A380 is a game-changer. Actually, I find it mildly surprising that it took 30 years or so for either Boeing or Airbus to take the 747 idea and extend the upper deck all the way. It's an ugly mofo too.
I think we're probably 15-20 years from the return of supersonic or even hypersonic travel, and that will be the next game changer. I might just fit a flight in before I shuffle off to the business lounge in the sky.