"Planes" is a bit limiting for me.
The Montgolfier balloon that flew 120 years before the Wright brothers seems to have been a game-changer that started it all off.
But the Boeing/North American/Douglas/Grumman -built Saturn V probably had as big a global impact as any other flying machine before or since.
LZ129 Hindenburg is another non-plane that will live in infamy for a long time too.