IMO, Planes that changed the world (the most) were catalysts of real change, sometimes coupled with a particular engine but, not necessarily the first in a particular speciality !
Wright Flyer
Fokker Eindecker
Gotha bomber
Supermarine S6
DC2/3
Spitfire
DH Mosquito
Me262
B29
B47
Bell X-1
DH Comet
Fairey Delta 2
F-111
747
Concorde
F14
Tornado IDS
Space Shuttle
A300 two-man flightdeck
F22
OAP