I think the concept, development and operational deployment of Barnes Wallis' Tallboy earthquake bomb were less radical than for his Upkeep bouncing bomb but I remain open to persuasion.
One could see it that way but the thing is that other people wanted tallboys afterwards and they were used again and again and on various targets from ships to sub pens. There are still penetration bombs to this day - not that I really know if they are "successors" to the Tallboy. So possibly it was less radical than the bouncing bombs but much more enduring and more widely useful.
Does that really say anything about the F-35? I don't know. From the outside it doesn't seem like the F-35 has had a hard time with money, only with self-created problems. It is only somewhat special purpose but if it sucks money out of other things then one might end up with war of some unexpected kind for which it is no particular use or at least ill-suited and no money to get something different.