All the previous info regarding D&D is out of date as now the D&D cell at Swanwick covers the whole of the UK including Scotland. As for 121.5 coverage I have not got a civerage chart to show but I do know the coverage over Scotland below 5000ft is very patchy.
As for the first post regarding losing comms with London information, as VHF is line of site there will be places if operating at low level and especially around higher terrain comms will be lost.
Being one of the voices of Scottish Information I know the areas and levels that I will lose comms with aircraft. If an aircraft is routing through one of those areas I will generally advise the flight that I expect to lose comms and where I would expect to regain comms.
If you do lose comms dont worry, we will not be too concerned but in general will normally phone your destination just to make sure you arrived safely although saying that there is no legal requirement to do so.
Hope this info helps.