Many advantages.
Power system (engine) can be placed where it is most effective aerodynamically and also with regard to C of G.
Imagine. The engines aft of the C of G away from passengers and fuel tanks.
However the propulsion can go anywhere the designer seems most effective.
Or vice versa. Engines up front, props at the back.
The powertrain redundancy for the V22 Osprey would certainly be a lot simpler.