I understand you are asking a complex combination:
You are landing an airport not in database + You did not create the runway where you plan to land + Still initially planned runway/airport remains in MCDU Flight plan ?
But still no problem:
If you have hard tuned ILS FREQ and Course (as overwriting the previous one), still you can fly ILS perfectly, however in scratch pad you will get an amber message similar to ILS TUNED AND RUNWAY MISMATCH. Besides, LAND mode will not appear and A/P will disconnect around 400 RA to prevent AUTOLAND because computer cannot compare runway direction and ILS course, for ALIGNMENT mode engagement for AUTOLAND (transparent to pilot).
EGPWS has a different database, if the airport where you are landing is not in its database you will definitely get warning. If it is in its database that I am not sure.