Pilot recruitment will change, battery psychometric testing to see if you have the slightest hint of being depressed. Hell most of us get depressed -because- of the industry and how we are treated. In fact there are scientific studies that show the pilot profession suffers from a high order of depression, nevermind that shiftwork itself is a prominent contributing factor.
As an aside, interestingly, liver function tests are never done in medicals to weed out alcoholics, and that hasn't happened even with the pilots they pull up with spot breath testing.