Originally Posted by AreOut
I see many people mention hypoxia, but shouldn't pilots have different resistance to it so one pilot would see the other pilot getting hypoxic and take appropriate measure? It's a very low probability that two different humans get hypoxic at the very same moment. (yeah I know about Helios and that one was strange too)
As a pilot of the sort of aircraft that is often flown considerably above 10,000ft with no oxygen (or indeed engine), I agree that different pilots report being very differently affected and onset beginning at widely differing altitudes.
Most of this discussion, however, has focused on rapid decompression and therefore rapid onset of hypoxia, way above any altitude where conditioning or physiological factors might come into play, so no difference in onset rate or effects would be noticeable.