Pah! Pressurisation, door seals, what's all this claptrap. More things to go wrong.
In the good 'ole days of the DC3 flying Gulf Aviation's (OK Gulf Air's) local routes, on several occasions the nearest passenger opened the emergency exit window in flight to get some cooler air.
It dropped down on its bottom hinge, and could be recovered pulling a piece of wire, which the steward did, once there were stewards. Before then it was the FO's job, but only after the crew finally noticed that the draught in the front was even stronger than usual.
JB here we come...........