While in-flight re-clearances are commonly done for diversions, the more common method for the situation you describe is to use a planned redispatch (PRD). With a PRD, the flight plan with ATC is to the intended destination, but the initial dispatch release to the crew is to an airport short of the destination. If the destination weather is acceptable and remaining fuel is above the prescribed minimum at the PRD fix enroute, a new Dispatch Release is sent to the crew, allowing them to continue to the final destination. ATC is not involved.
The PRD is like a brand-new flight plan (even though the actual flight plan with ATC never changes), so it also allows the use of no-alternate situations when the PRD fix is less than 6 hours from the destination.