I actually got lost on my QXC. I was between Stansted and Luton on my way back to Elstree and couldn't be sure of my position.
Instead of guess and run the risk of busting someone's airspace I used 121.5 to tell them. About a millisecond after I stopped transmitting I had a reply. They also gave me a heading to Elstree, and stayed with me until I had Elstree in sight.
IMO the most important thing is to accept you're not infallible, swallow your pride and ask for help.
However, that only counts in the air: in the car with my wife next to me, I would never admit to being lost, because I never am...ever!