Back in the day a friend departed in poor vis in a Cessna 402 which had an alternate static port in the nose baggage compartment. The static source selector valve had previously failed to the alternate source, undetected.
After take-off a baggage door popped open, ejecta damaged the left prop, and in the subsequent NDB approach to the Arctic strip they descended into the snow pack while indicating over 500' AGL. The two pilots survived, just.
The altitude error combined with the ambient conditions almost killed them.