Beer Baron-
Do you fill the fuel tanks to the brim (or MTOW) for every flight? Surely that is safer?
Do you refuse all intersection departures (LHR 09R-N10, LAX 25R-F)? Why accept it, it reduces your safety margin and you are the Captain!
Filling the tanks to brim (or MTOW) makes no difference to the safety margin.
Intersection departures when properly calculated, do not reduce the safety margin.
There is no difference in flying technique in take off of you are doing a flex or Toga takeoff- however the flying techniques in landing with xwind/tailwind with a heavy aircraft after a ULR flight is a completely different kettle of fish.