As an instructor I see a lot of pilots and there cetainly seem to be a lot of left-handed ones. I once worked for an organisation employing about 50 instructors; 6 of us were picked to set up an instructor training course and at the first meeting we found that 5 of the 6 were left-handed!
In the military, with a control column held in the right hand and a throttle on the left, being left-handed was useful when it came to writing things down (as it is for me in the right-hand, instructor's seat nowadays).
I can only reacall personally one instance of getting my hand actions round the wrong way and that was a very early right-hand seat trip in a glider when I flared with the spoilers and eased the stick in (forward) - not a pretty landing.