A few months ago I stepped straight out of a day in a PA-28 into a pilot's shop - and there was a full demonstrator PA-28 Flight Simulator setup all ready to go - yoke, pedal unit, hand throttle, the lot.
Just couldn't get to grips with it at all. The same as Genghis describes above. I think in particular the 2-D monitor display just doesn't give you the depth perception on flaring.