I'm only a lowly PPL student at the latter stages of the course, but as i am left-handed, i thought i'd mention my experiences.
Being a left-hander hasn't been a real problem, but the only difficulties (and this may be only relevent to students) is when writing ATC messages down on my kneeboaed. When i was taught to fly, i was always told to put my left hand on the yoke. Later, when i was at the navigating section of the course, and ATC would give me all sorts of clearances or whatever, i tried to write down it down with my right hand. I couldn't do it - because i wans't quick enough or neat enough. So now i remove my left hand form the yoke, and switch my right-hand to the yoke. This is simple for me now, but when i first started flying lessons, the yoke would be 'unnattended' for quite a few seconds - while my instructor would witness my ineptitude with startled eyes.
Hope this is the sort of thing you're looking for!