I would be confident that the F35 would be up for a 60 year life cycle if the main structure and propulsion units of the project were up to it.
Yes it can be argued that Moore's Law about the power of computers gives the F35 wonderful opportunities to do fantastic things in the next decades.
The ability to do these wonderful things in future decades requires that the stress problems in the B version and serious engine problems in all the versions and as yet uncertified software all get sorted out rather quickly.
I sadly rather doubt that the present apparent problems will be sorted out in time for the USMC to declare IOC in May 2015, what this means for the Royal Navy's aircraft carriers is of course a completely other matter.