Versatility wise there is no other option - it can lift 115,000KGs, fly for 7+ hours, is great hot & high, and is so over-powered it's a dream. Add great brakes and there really is no other airliner like it. It's also by far the best looking airliner - everything is in proportion and winglets really finish it off.
Agree with all of these things, especially the last sentence. My favorite view of a 757 is when it is coming in to land. Those long gear legs hanging down. It looks just like an eagle or a vulture coming down to snatch up some prey with its talons.
My understanding is that it is so over-powered that it can do touch-and-goes with only one engine. So no commitment to land if a single engine approach gets stuffed.