Ibuprofen is not the friendliest sort of medication as far as the kidneys are concerned. Paracetamol might serve them better.
As for the smokes, well, endless monologues have been written on how lucky some are who have given them up. Here's another one then, a monologue that is. Up until relatively recently bladder cancer was almost exclusively a male disease. It wasn't quite as sexually restricted as prostate cancer but it came a close second. In the last few decades the linear representation of bladder cancer statistics as between men and women has almost evened itself out. The correlation between the increase in smoking among women and the rise in bladder cancers among that sex is too obvious to ignore. Smoking cigarettes is the single largest cause of bladder cancer and, because that one often has few symptoms until well advanced, it's a nasty little problem for some. Bladderless is not where you want to be.
Anthrax was almost exclusively a male problem too but, unless overly badgered, I'll save that little medical snippet for another day.