Ofcourse it is an issue.
Anybody who spent some time in Africa, knows.
Part of the job, I guess.
I Remember a FO scotch tape his hotel room door during a layover.
I remember another guy jumpseating to Europe for 'better treatment' for his bad cold and headaches. He died from meningites a few days later.
You do not get those things from flying 'around the church' in Europe.