As I recall reading, the AN225 was never intended for commercial use, and was only designed for transporting the Buran shuttle. The biggest problem (and expense) in making it a viable heavy hauler was getting the original military specification upgraded to meet international civil aviation requirements. Presumably, now this process has been done once, it would make it much easier to do the same with the other airframe linked above. However if money is tight (and considering the political situation in Ukraine at the moment), this could be a long way off!