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Not at all. The time to deal with bladder problems on a long flight is before you take off! Well equipped with containers (plastic bags) that won't leak.
And you lads are well equipped in other ways as well....as the little girl said to the little boy, that's a handy thing to have on a picnic!
There are Eastern European gliders that have plumbing arrangements for passing fluids directly overboard.
And some entrepeneurs promise that female contraptions are available to meet the needs of the lady pilots. Some girls wear Depends, which is what the astronauts now do while waiting on the launchpad....but I used to sit on a couple of bath towels, worked for me.
My longest flight was 8 hours and 53 minutes, covering a task of 511 k.
One does not want to be distracted by mundane physical problems. Also I am informed that if you are going to crash, it is dangerous to crash with a full bladder!