On the type I fly (no auto throttle), cruise airspeed is close to Vne. Flying with ALT selected in turbulence will result in what can be quite an alarming phugoid flight path and a Vne excursion, or at least an airspeed audio warning, which is recorded in the data base.
VS mode is relatively benign.
It's a matter of knowing your aircraft, rather than a "one size fits all" answer.