Hi - funny you should ask that; while I have nowhere near that many flt. hrs., I have asked the same question at a recent Airline Orientation Training recruitment seminar; they (they're all F/Os and Capts) agreed that twin hrs. were what airlines were interested in, NOT SEP.
However, they reckoned that MEP hrs, particularly IFR, were expensive to say the least, so they recommended to keep current by doing 1-2 hrs/month on a flight sim; turns out way cheaper, and apparently looks better than extra SEP time on a CV.
Cheers