trim downwind rudder while enroute so that crosswind component doesn't affect the vertical stabilizer
Wha?
Cross-wind doesn't affect anything with regards to trim. The airplane doesn't know what the wind is...
Edit: Oh I see you got it from this:
Planes with winglets struggle to stay in LNAV due to crosswind pushing on winglets
Again, the airplane doesn't know what the wind is. It just flies in the body of air, whether the body of air itself is moving or not. The idea that an airplane will struggle to stay in LNAV due to a cross wind is just plain silly.
The earlier poster mentioned gusts on approach. Gusts will change the aircraft's flight, due to inertia. That plus when you're on approach, you're flying relative to the ground.
While enroute, in a stable condition, wind doesn't affect how any airplane flies. You (without autopilot/FMS/etc.) just point it a little upwind to compensate for it.