When I was living in SF Bay Area, I did the trip to Lake Tahoe several times in an old 145hp light single, so yes, it is doable. Be careful with weather on that route and calculate +50% on top of your personal risk capability.
Due to the mountains, you will face good weather on one side and very bad on the other - many times - so do not rely on taking the plane.
Good alternate routes are crossing Crystal Bay and join 80 overhead Truckee, or go South and follow Mokelumne River (only and only if in very! good weather, it's spectacular but tricky).
Depending on the plane going direct on top might be a bit on the edge.