Could you please elaborate on Hypoxia (or for that matter aircraft air supply suddenly contaminated with some kind of life ending substance). I believe this is the only angle that has not been debated to death on this forum.
Slow pinhole leaks can be as dangerous as a rapid decompression. The resulting insidious onset of hypoxia on the brain can be similar to alcohol intoxication. The effects vary by individual: impaired cognitive function, euphoria and overconfidence, lethargy or angry and un-cooperative. There are sensors and alarms to warn of loss in cabin pressure which should result in immediate action.
Helios Airways Flight 522 is a tragic example.