Ronald R, the US of A was built as an integral part of global trade, as far back as 1607 and the Jamestown economy. Isolationism is not a valid policy position as a major international trade participant now. How one should pursue one's interests and keep trade lines safe is a matter of degree, not kind.
Where one has trade one often has interests.
I'll go no further down that rat hole. The discussion here regards the Ukraine. Since the US and Russia BOTH signed off on the security guarantee for Ukraine in 1994, both parties have an expressed interest in Ukraine's future.