As with Desert above I was lucky in being involved with a Bournemouth company and it was very much the case of can you take that! Never flown one was met with you will be fine
On a somewhat complex airplane like a 421, Baron or a Skymaster 337, etc., at the very least I would visually check for adequate fuel in the tanks, know the fuel system, know the emergency gear extend and know Vmc, if applicable (this was before red and blue lines on the AI)...and of course, a guy has to know his limitations.