Is it easier to relax in a 'Bus with the sidestick? I'd say so, but I only fly the 20/21 so the sectors aren't that long.
Perhaps a 330/340 driver can tell you more.
I just like having somewhere to put dindins without all that balancing on your knees malarkey... I've heard you can spot a long-haul Boeing driver as he's always got food on his trousers!