IM a GA pilot, DAME and an enthusiastic aviation consumer.
As a previous fairly regular Qantas customer to Europe 1-3 times a year for 25 years, my feedback would be that Singapore is really the only Asian City the dear wife will put up with. A distant second choice is Bangkok .
Obviously there is no real discussion about matters of taste, but if a safe clean peaceful rest on the way over is what you want, we have to take the second leg via Singapore Airlines .
We don't (never will) do the Middle East. Period. ( again, a matter of consumer taste).
So thats what we do - Qantas to Singapore, then Singapore Airlines to LHR.