Good luck finding an insurance company who will insure pilotless aircraft.
Freight............maybe.......500 pax....not in the next 50 years or unless there is some sort of communication technology revolution.
Who will pay for all the satcom bandwidth is the next question to ask.
Note that the "Pilotless" aircraft now in use by the military still have Human operators.
Anyone know how many they lose control of due com failures and other problems?