Courtney ... my question was really a bit "tongue-in-cheek"
But I guess if you got in the right place with one of these you could do some serious damage
The Me262A-1/U4 or "Pulkzerstörer" (Formation or Pack Destroyer)
Apparently only two prototypes of this model were constructed and flown, featuring the 50 mm Rheinmetall-Borsig Mk 214 cannon.
The fitting of the Mk214 to the Me 262 was an effort to create an effective bomber-killer that could attack enemy formations from long range without being subjected to the bomber's defensive fire. The gun fired 1.5-kg shells at a muzzle velocity of 1100 meters/second, with the 2400kg recoil of the weapon being absorbed by a hydraulic damper. It was estimated that a single hit would be sufficient to cripple an Allied bomber. This development was designated the Me262A-1/U4 and was known as the "Pulkzerstörer" (formation or pack destroyer).