adfly - are you asking about whether an aircraft is physically capable of performing a flight between 2 airports with a full cabin, or are you asking about whether the aircraft would be commercially viable ?
Plenty of competing flights to AGP / ALC / PMI / FAO / NCE on larger aircraft than an E175 with lower unit cost to the airline per passenger. Very few competing flights to the tourist honeypot that is Florence, particularly from LCCs.
Admittedly Pisa central station, 1 mile from the airport, has a good train service to Florence centre though...
Last edited by davidjohnson6; 4th Feb 2014 at 15:03.