With the greatest respect to CaptPPrune, I have to agree with Boeing Boy.
Whilst I have no respect for our media friend who proceeded to do it on TV, I believe that coordinated people with limited actual flight experience could do this. Not even a PPL required just an hour in the right hand seat of a jet, be it a Citation Bravo or a Lear 45 or something equally small. Most glass cockpits are easy to drive in autopilot of you know what to do and where you are.
Try X-plane or FS2000, they even have all the enroute info for you, VOR's, NDB's et al. The GPS is also accurate.
A tragedy made simpler to accomplish by the wonders of modern technology, all for $39.99.
The world will never be the same again.