Every market (and market segment) is going to be different.
You have markets with many non-stop flights (LHR-JFK/EWR or LON-GVA),
You have markets with a few non-stop flights (LHR-YYZ)
You have markets with one 'direct' flight (GVA-YYZ)
You have markets with no non-stops but with a few single on-line connections (GVA-YVR: via LHR, AMS, FRA, YUL)
You have markets with only interline connections (AMS-YXS)
To offer a connecting service LHR-JFK or LON-GVA, for the business market you will have to be a lot cheaper. For the VFR/Tourist market - quite a bit cheaper.
LHR-YYZ connecting service the schedule is likely to be as important as the price. Same with GVA-YYZ.
GVA-YVR - Everyone is connecting - price much less important as long as you are 'competitive'
AMS-YXS - Sum of sectors plus all of the above.