I wonder how many totally innocent people have died as a result, and who even cares?
The Rules of Engagement for a Reaper/Predator are
exactly the same as a manned aircraft. The big thing is, as you can see in the post above, that the Reaper/Predator has better situational awareness through its vast array of sensors and intelligence feeds and it can loiter until the target is confirmed - unlike a fast jet that is quickly running out of fuel and will need to go to the tanker within 30 minutes.
I know that the crews care far more than the press would give them credit. After all no-one wants to be accused of illegal acts and being accused of being a war criminal.