To have one engine remaining on any multi engine jet transport is a serious situation, the big twins are certified to operate on one and land as soon as possible.
This is why ETOPS was invented, to cater and allow for an unthinkable possibility in the age of three and four engine jets.
Those earlier aircraft had built in redundancy allowing you to continue with the loss of one powerplant.
Nothing has changed except the 'twin minded' assume every engine failure is an emergency regardless of how many you have remaining.