Ever seen anA380 land on 27, no. It uses full length 34
No problem on a dry runway but the factored landing distance on a wet runway became an issue* some months back when Airbus altered their method of calculating the landing performance…..* for the Australian A380 operator anyway ; not sure about the others.
This issue is now resolved but if 27 is in use and 34 is available without a significant crosswind, many would prefer/require 16/34. There is also a note on the Melbourne A380 taxi chart that a runway inspection is required after a 09/27 arrival or departure, probably as it is a 45m runway.