PPRuNe Forums - View Single Post - NAPs - To take or not to take?
View Single Post
Old 22nd Mar 2003, 18:11
  #2 (permalink)  
WhichWay?
 
Join Date: May 2001
Location: Trucky Field at 512ft, UK
Posts: 50
Likes: 0
Received 0 Likes on 0 Posts
This question passed my mind so I asked my pharmacist wife to do some research. The following is from the Journal of the American Medical Association.

Vol. 266 No. 5, August 7, 1991

ARTICLE


Pyridostigmine used as a nerve agent pretreatment under wartime conditions
J. R. Keeler, C. G. Hurst and M. A. Dunn
US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Md. 21010-5425.

OBJECTIVE. To determine the adverse effects of pretreatment with pyridostigmine bromide for nerve agent exposure during wartime. DESIGN. A retrospective study. SETTING. Southwest Asia. PARTICIPANTS. Personnel who provided medical support to the XVIII Airborne Corps. These medical officers supplied information pertaining to symptoms and disposition of 41,650 soldiers who received pyridostigmine at the onset of hostilities of Operation Desert Storm. INTERVENTION. Pyridostigmine bromide, 30 mg orally, was self-administered every 8 hours while under the threat of nerve agent attack (for 1 to 7 days). MAIN OUTCOME MEASURE. Physiologic changes attributable to pyridostigmine that resulted in need for medical attention, discontinuation of the drug, hospitalization, and/or evacuation from Southwest Asia. RESULTS. About half of the population noted physiologic changes that were not incapacitating, such as increased flatus, abdominal cramps, soft stools, and urinary urgency. Approximately 1% of the soldiers believed they had effects that warranted medical attention, but fewer than 0.1% had effects sufficient to discontinue the drug. Nonincapacitating symptoms often occurred; however, military mission performance was not impaired. CONCLUSION. While under the threat of nerve agent attack, pyridostigmine can be administered to virtually all soldiers.


Good enough for me and it's better than nerve agent poisoning, which is exactly what you will get if you OD on NAPS as it works the same way by blocking the nerve messages but NAPS can be broken down by the body whereas Organo-Phosphates (basis of nerve agents) cannot.

WW

But then again you have been ordered to take them
WhichWay? is offline