I have had a C-185 with IO-520 (with GAMIjectors) and an 86" Mac prop (noise) going on 14 years. During that time, I have left the throttle at max and reduced the RPM from 2850 to 2500.
Tests (including mine) show that the cylinder head temps tend to rise above 400 in the climb when reducing power to 25/2500. Leaving the throttle at WOT and leaning during the climb to maintain 1200-1250 EGT (which is my EGT at sea level just after takeoff) results in cool CHT's. This technique works quite well at sea level or at much higher elevations. I religiously keep my CHT's below 380.
As a side note, the cylinders are original Continental with over 1200 hours. Never removed. Good compressions and good oil analysis. WOTLOPSOP, indeed.
