Oh for the days when I'd go and do six 52 mile sectors in the morning in a DC-9.
Being a green and keen F/O in those days I never turned on the autopilot. Jaded skippers did, but not for long, takeoff to touchdown was about 12 minutes at 250 knots and 11 minutes at 320 knots.
It almost seemed like one continuous reading of the checklist from start to finish.
And when your navigation equipment consisted of 2 VOR's and 2 ADF's you could have your airplane set up for the return flight in under a minute.