L_R_T, aileron would probably not be a big issue in some types, but with a high lift wing and lots of power on the operating engine, there is a large amount of aileron required to counteract the rolling tendency towards the dead engine.
With a big rudder effective down to low speeds, aileron becomes a significant factor in that you end up with the control wheel screwed around towards the live and may not have a heap left, before you run out of rudder.